HIP1R

Across TCGA cell cohorts, HIP1R mutation is significantly associated with the RNA expression of many other genes, with 596 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HIP1R-associated genes across cancer lineages are OR1L3, PRSS58, and ST13. Each is linked with HIP1R in more than 2 cancer types. Because this analysis shows association rather than direction, both HIP1R-to-partner and partner-to-HIP1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by HIP1R-low versus HIP1R-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIP1R→partner) and Y-score (partner→HIP1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR1L3 →	+0.026	+3.700	<.001	.003	3	3
CNS	PRSS58 →	+0.069	+3.700	<.001	.003	3	2
LARGE_INTESTINE	ST13 →	+0.466	+3.321	.003	.003	3	2
LARGE_INTESTINE	LYG1 →	+0.886	+2.743	<.001	.001	3	2
LARGE_INTESTINE	PPID →	+0.602	+3.321	<.001	.002	3	2
LARGE_INTESTINE	NIPSNAP1 →	+0.690	+2.459	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 596 associations by consensus.

OR1L3 by HIP1R expression — CNS

Explore this box plot interactively →