HILPDA

Across TCGA patient cohorts, HILPDA protein abundance is significantly associated with the RNA expression of many other genes, with 5,647 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HILPDA-associated genes across cancer lineages are PTGFR, EMB, and KISS1R. Each is linked with HILPDA in more than 2 cancer types. Because this analysis shows association rather than direction, both HILPDA-to-partner and partner-to-HILPDA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HILPDA versus PTGFR in CCRCC, with a Pearson correlation of -0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HILPDA→partner) and Y-score (partner→HILPDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PTGFR →	-1.274	-0.765	.005	.002	3	3
BRCA	EMB →	-1.530	-1.263	<.001	.002	3	3
CCRCC	KISS1R →	+1.608	+0.707	.003	.003	3	3
CCRCC	PPM1K →	-0.664	-0.869	.006	<.001	3	3
CCRCC	GAPDHP63 →	+0.651	+0.649	<.001	.001	3	3
UCEC	SPIN1 →	-0.622	-0.685	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,647 associations by consensus.

HILPDA vs PTGFR — CCRCC

Explore this scatter interactively →