HILPDA

Across TCGA pan-cancer cohorts, HILPDA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HILPDA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HILPDA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HILPDA is over-expressed in tumor.

KIRC, COAD, and LUAD are the cancer types where HILPDA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HILPDA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+4.779	<.001	12	view →
COAD	Female	II,III,IV	+2.600	<.001	11	view →
LUAD	Male	All	+1.536	<.001	11	view →
HNSC	All	II,III,IV	+1.085	<.001	9	view →
BLCA	Male	III,IV	+3.002	<.001	8	view →
LIHC	All	II,III,IV	+1.301	<.001	8	view →
READ	Female	All	+2.162	<.001	7	view →
KIRP	All	All	+0.971	<.001	7	view →
UCEC	All	III,IV	+2.804	<.001	6	view →
LUSC	Female	All	+1.623	<.001	6	view →
BRCA	Female	II,III,IV	+0.611	<.001	6	view →
CHOL	Male	All	+2.500	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HILPDA–KIRC

Open the KIRC breakdown →