Q-omics provides the consensus-scored HIKESHIP3 profile across patient tissues and cancer cell-line models. HIKESHIP3 expression is associated with patient survival in 12 of 34 cancer types, with the highest sampling consensus in THCA. Additionally, HIKESHIP3 RNA expression shows 6,339 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight THCA, and STAD as cancer lineages where HIKESHIP3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes HIKESHIP3 survival associations across molecular data types. HIKESHIP3 RNA expression shows survival associations in the most cancer types (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

HIKESHIP3 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	12	THCA (84)	view →

This table ranks reproducible HIKESHIP3 RNA expression–survival associations across cancer types. High HIKESHIP3 expression shows unfavorable associations in THCA, LUSC, ACC, ESCA, SKCM and OV. The THCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify THCA as the clearest survival context for HIKESHIP3 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	All	0.729	0.933	<.001	84	view →
LUSC	OS	Tertile	III,IV	0.167	0.784	<.001	57	view →
ACC	OS	Tertile	All	0.114	0.892	<.001	36	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	30	view →
SKCM	DFS	Tertile	IV	0.045	0.477	.005	18	view →
OV	DFS	Quartile	IV	0.300	0.523	.017	18	view →

Pink = unfavorable, green = favorable. all 12 lineages →

HIKESHIP3-THCA (OS)

Kaplan–Meier survival curve for HIKESHIP3 RNA expression in THCA: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with HIKESHIP3 in patient tissues and cancer cell lines. In patient samples, HIKESHIP3 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	6,339	STAD (5733)	view →
RNA	5,213	THYM (2289)	view →