HIKESHIP3

Across TCGA pan-cancer cohorts, HIKESHIP3 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated HIKESHIP3 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher HIKESHIP3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HIKESHIP3 expression acts as an unfavorable survival marker.

THCA, LUSC, and ACC are the cancer types where HIKESHIP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	All	0.729	0.933	<.001	84	view →
LUSC	OS	Tertile	III,IV	0.167	0.784	<.001	57	view →
ACC	OS	Tertile	All	0.114	0.892	<.001	36	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	30	view →
SKCM	DFS	Tertile	IV	0.045	0.477	.005	18	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	18	view →
READ	OS	Tertile	All	0.528	0.932	<.001	18	view →
OV	DFS	Quartile	IV	0.300	0.523	.017	18	view →
UCEC	DFS	Tertile	IV	0.206	0.704	.033	18	view →
BRCA	DFS	Tertile	All	0.845	0.907	.014	15	view →
KIRC	DFS	Tertile	II,III,IV	0.644	0.782	.033	6	view →
LIHC	OS	Tertile	All	0.185	0.490	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

HIKESHIP3–THCA (OS)

Open the THCA breakdown →