HIGD2B

Across TCGA patient cohorts, HIGD2B mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HIGD2B-associated genes across cancer lineages are COX6CP12, ARHGAP42P3, and LINC02559. Each is linked with HIGD2B in more than 1 cancer types. Because this analysis shows association rather than direction, both HIGD2B-to-partner and partner-to-HIGD2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6CP12 grouped by HIGD2B-low versus HIGD2B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIGD2B→partner) and Y-score (partner→HIGD2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	COX6CP12 →	+0.212	+5.513	<.001	.004	3	1
SKCM	ARHGAP42P3 →	+0.019	+6.624	<.001	.001	3	1
SKCM	LINC02559 →	+0.263	+6.624	<.001	.001	3	1
SKCM	NMBR-AS1 →	+0.220	+5.513	<.001	.004	3	1
SKCM	TIMM9P1 →	+0.322	+4.979	<.001	.009	3	1
SKCM	ACTR3P3 →	+0.049	+5.594	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

COX6CP12 by HIGD2B expression — SKCM

Explore this box plot interactively →