HIGD2B

Across TCGA pan-cancer cohorts, HIGD2B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HIGD2B data layer compared with 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HIGD2B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HIGD2B expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, COAD, and KIRC are the cancer types where HIGD2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.739	0.620	.001	52	view →
COAD	DFS	Median	II,III,IV	0.392	0.698	.003	45	view →
KIRC	DFS	Median	III,IV	0.553	0.721	.008	35	view →
KIRP	DFS	Median	IV	0.038	0.594	.004	25	view →
THCA	OS	Quartile	IV	0.754	1.000	.010	25	view →
STAD	OS	Median	IV	0.806	0.204	<.001	24	view →
LUSC	OS	Median	III,IV	0.581	0.764	.002	20	view →
UCS	OS	Tertile	IV	1.000	0.276	.018	18	view →
GBM	DFS	Median	All	0.188	0.379	.002	9	view →
READ	OS	Tertile	IV	0.878	0.535	.020	9	view →
PAAD	DFS	Quartile	All	0.332	0.558	.012	6	view →
LUAD	OS	Quartile	II,III,IV	0.402	0.601	.045	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HIGD2B–UCEC (DFS)

Open the UCEC breakdown →