HIGD1AP12

Across TCGA patient cohorts, HIGD1AP12 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,221 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HIGD1AP12-associated GO terms across cancer lineages are Protein quality control for misfolded or incompletely synthesized proteins, Protein modification by small protein removal, and Positive regulation of RNA splicing. Each is linked with HIGD1AP12 in more than 12 cancer types. Because this analysis shows association rather than direction, both HIGD1AP12-to-partner and partner-to-HIGD1AP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein quality control for misfolded or incompletely synthesized proteins grouped by HIGD1AP12-low versus HIGD1AP12-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIGD1AP12→partner) and Y-score (partner→HIGD1AP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Protein quality control for misfolded or incompletely synthesized proteins →	+0.050	+0.360	.002	<.001	3	13
STAD	Protein modification by small protein removal →	+0.038	+0.154	<.001	<.001	3	12
STAD	Positive regulation of RNA splicing →	+0.039	+0.130	<.001	<.001	3	11
STAD	Cellular lipid catabolic process →	+0.022	+0.157	<.001	<.001	3	11
STAD	Regulation of mRNA 3'-end processing →	+0.047	+0.211	<.001	<.001	3	11
STAD	Regulation of cellular ketone metabolic process →	+0.018	+0.123	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,221 associations by consensus.

Protein quality control for misfolded or incompletely synthesized proteins by HIGD1AP12 expression — ESCA

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