HIGD1AP12

Across TCGA pan-cancer cohorts, HIGD1AP12 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated HIGD1AP12 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HIGD1AP12 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HIGD1AP12 expression acts as an unfavorable survival marker, although some lineages such as SKCM and TGCT show a favorable association.

UCEC, MESO, and KIRC are the cancer types where HIGD1AP12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.501	0.677	<.001	102	view →
MESO	OS	Tertile	All	0.052	0.528	.016	54	view →
KIRC	DFS	Quartile	III,IV	0.440	0.700	.009	46	view →
THCA	OS	Tertile	IV	0.252	1.000	<.001	42	view →
KICH	OS	Tertile	II,III,IV	0.834	1.000	.002	34	view →
SKCM	DFS	Tertile	III,IV	0.716	0.470	.009	33	view →
KIRP	OS	Quartile	III,IV	0.446	0.721	.022	15	view →
DLBC	OS	Tertile	II,III,IV	0.118	0.802	.025	12	view →
TGCT	DFS	Tertile	All	0.907	0.730	.024	10	view →
SARC	DFS	Tertile	All	0.135	0.424	.020	9	view →
STAD	DFS	Tertile	II,III,IV	0.401	0.562	.030	3	view →
LGG	DFS	Quartile	All	0.289	0.420	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

HIGD1AP12–UCEC (DFS)

Open the UCEC breakdown →