HIC2

Across TCGA patient cohorts, HIC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,777 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HIC2-associated proteins across cancer lineages are MORC2, ZMYM2, and SMARCD1. Each is linked with HIC2 in more than 5 cancer types. Because this analysis shows association rather than direction, both HIC2-to-partner and partner-to-HIC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HIC2 versus MORC2 in GBM, with a Pearson correlation of 0.61.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HIC2→partner) and Y-score (partner→HIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MORC2 →	+0.371	+0.580	<.001	<.001	3	6
LSCC	ZMYM2 →	+0.350	+0.525	<.001	<.001	3	6
GBM	SMARCD1 →	+0.354	+0.515	<.001	<.001	3	5
GBM	SMC3 →	+0.525	+0.678	<.001	<.001	3	5
GBM	NIPBL →	+0.339	+0.595	<.001	<.001	3	5
GBM	CTNNBL1 →	+0.251	+0.434	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,777 associations by consensus.

HIC2 vs MORC2 — GBM

Explore this scatter interactively →