HIC2

Across TCGA pan-cancer cohorts, HIC2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HIC2 data layer compared with 5 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HIC2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HIC2 expression acts as an unfavorable survival marker, although some lineages such as READ and KIRC show a favorable association.

ACC, READ, and LIHC are the cancer types where HIC2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.388	0.826	<.001	145	view →
READ	OS	Tertile	II,III,IV	1.000	0.233	.001	35	view →
LIHC	DFS	Quartile	All	0.431	0.633	<.001	34	view →
KIRC	OS	Median	All	0.851	0.760	<.001	34	view →
HNSC	DFS	Tertile	IV	0.763	0.553	.002	32	view →
LUSC	DFS	Quartile	III,IV	0.559	0.905	.006	24	view →
UCEC	OS	Tertile	All	0.878	0.948	.009	20	view →
UCS	OS	Tertile	II,III,IV	0.779	0.444	.027	18	view →
GBM	DFS	Median	All	0.401	0.179	<.001	18	view →
PAAD	OS	Tertile	All	0.601	0.410	.015	17	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.528	.017	11	view →
THCA	OS	Tertile	All	0.949	1.000	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HIC2–ACC (OS)

Open the ACC breakdown →