HIC2

Across TCGA pan-cancer cohorts, HIC2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HIC2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HIC2 RNA is repressed in tumor relative to normal tissue. In most cancer types HIC2 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, LIHC, and BLCA are the cancer types where HIC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HIC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.104	<.001	10	view →
LIHC	Female	II,III,IV	+1.120	<.001	8	view →
BLCA	Male	All	+1.294	.005	6	view →
STAD	All	II,III,IV	+0.632	.001	6	view →
HNSC	Male	All	+0.592	<.001	6	view →
KIRC	All	All	+0.269	<.001	6	view →
LUSC	Male	All	+0.762	<.001	5	view →
BRCA	Female	II,III,IV	−0.293	<.001	4	view →
CHOL	Male	All	+1.636	<.001	2	view →
KIRP	All	All	−0.306	.007	2	view →
LUAD	All	All	−0.251	.004	2	view →
PRAD	All	All	+0.185	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HIC2–THCA

Open the THCA breakdown →