HIC2

Across TCGA patient cohorts, HIC2 mutation is significantly associated with the RNA expression of many other genes, with 6,035 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIC2-associated genes across cancer lineages are TXNL1, ENO2, and KIF20A. Each is linked with HIC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HIC2-to-partner and partner-to-HIC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNL1 grouped by HIC2-low versus HIC2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIC2→partner) and Y-score (partner→HIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TXNL1 →	+0.516	+3.223	.002	.009	3	3
UCEC	ENO2 →	+0.840	+1.887	<.001	<.001	3	3
UCEC	KIF20A →	+0.619	+2.088	<.001	<.001	3	3
UCEC	DENND10 →	+0.327	+1.544	<.001	<.001	3	3
UCEC	CCNB1 →	+0.759	+3.070	<.001	<.001	3	3
UCEC	NARS1 →	+0.471	+2.078	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,035 associations by consensus.

TXNL1 by HIC2 expression — COAD

Explore this box plot interactively →