HIC2

Across TCGA cell cohorts, HIC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,950 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HIC2-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and Regulation of DNA repair. Each is linked with HIC2 in more than 19 cancer types. Because this analysis shows association rather than direction, both HIC2-to-partner and partner-to-HIC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by HIC2-low versus HIC2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIC2→partner) and Y-score (partner→HIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Symbiont-mediated disruption of host cellular anatomical structure →	+0.155	+1.534	<.001	<.001	3	20
SOFT_TISSUE	Symbiont-mediated disruption of host anatomical structure →	+0.155	+1.534	<.001	<.001	3	20
LIVER	Regulation of DNA repair →	+0.075	+2.071	<.001	<.001	3	16
BLOOD_Lymphoma	Protein-DNA complex organization →	+0.058	+0.833	<.001	<.001	3	16
LARGE_INTESTINE	Negative regulation of chromosome condensation →	+0.145	+1.007	<.001	<.001	3	15
BLOOD_Lymphoma	Positive regulation of mRNA metabolic process →	+0.081	+0.902	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,950 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by HIC2 expression — SOFT_TISSUE

Explore this box plot interactively →