HIC2

Across TCGA cell cohorts, HIC2 mutation is significantly associated with the RNA expression of many other genes, with 297 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HIC2-associated genes across cancer lineages are IQCF5, OR10T2, and GPS2. Each is linked with HIC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HIC2-to-partner and partner-to-HIC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by HIC2-low versus HIC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIC2→partner) and Y-score (partner→HIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.052	+3.201	<.001	.005	3	3
BLOOD_Leukemia	OR10T2 →	+0.490	+3.013	<.001	.001	3	2
LARGE_INTESTINE	GPS2 →	+0.521	+3.212	.007	.006	3	2
LARGE_INTESTINE	ZNF48 →	+0.620	+3.212	.001	.006	3	2
OESOPHAGUS	TDRD15 →	+0.006	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	CEACAM4 →	+0.046	+4.927	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 297 associations by consensus.

IQCF5 by HIC2 expression — BLOOD_Leukemia

Explore this box plot interactively →