Across TCGA patient cohorts, HHLA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,141 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible HHLA3-associated GO terms across cancer lineages are Cytoplasmic sequestering of NF-kappaB, Axoneme assembly, and N-terminal peptidyl-methionine acetylation. Each is linked with HHLA3 in more than 17 cancer types. Because this analysis shows association rather than direction, both HHLA3-to-partner and partner-to-HHLA3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA3→partner) and Y-score (partner→HHLA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	Cytoplasmic sequestering of NF-kappaB →	+0.048	+0.736	<.001	<.001	3	18
UCEC	Axoneme assembly →	+0.038	+0.315	<.001	<.001	3	16
DLBC	N-terminal peptidyl-methionine acetylation →	-0.055	-0.674	.001	.001	2	16
THCA	Peroxisome fission →	+0.051	+0.425	<.001	<.001	3	14
GBM	Luteinization →	-0.062	-0.590	<.001	<.001	3	14
DLBC	Binding of sperm to zona pellucida →	-0.062	-0.567	.002	.007	1	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,141 associations by consensus.

Exploration

HHLA3 survival (RNA) · tumor vs normal (RNA) · all HHLA3 data types