HEXB

Across TCGA patient cohorts, HEXB mutation is significantly associated with the RNA expression of many other genes, with 1,587 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEXB-associated genes across cancer lineages are MTND5P5, OR10AA1P, and RNU6-502P. Each is linked with HEXB in more than 1 cancer types. Because this analysis shows association rather than direction, both HEXB-to-partner and partner-to-HEXB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND5P5 grouped by HEXB-low versus HEXB-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXB→partner) and Y-score (partner→HEXB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MTND5P5 →	+0.109	+6.144	<.001	.001	3	2
COAD	OR10AA1P →	+0.584	+5.693	<.001	.003	3	2
CESC	RNU6-502P →	+0.298	+5.418	<.001	.005	3	2
UCEC	RNY1P8 →	+0.292	+3.038	<.001	.006	3	2
UCEC	RNA5SP420 →	+0.390	+2.507	.007	<.001	3	2
BLCA	RNU6-597P →	+0.353	+4.685	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,587 associations by consensus.

MTND5P5 by HEXB expression — CESC

Explore this box plot interactively →