HEXB

Across TCGA pan-cancer cohorts, HEXB RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HEXB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HEXB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HEXB is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where HEXB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HEXB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.432	<.001	12	view →
KIRC	Female	III,IV	+0.854	<.001	12	view →
LIHC	Male	II,III,IV	+1.135	<.001	8	view →
LUSC	Female	All	−0.745	<.001	7	view →
KIRP	Male	II,III,IV	+0.966	<.001	6	view →
STAD	Male	II,III,IV	+0.955	<.001	6	view →
LUAD	All	All	−0.254	.006	5	view →
COAD	Male	All	+0.475	<.001	4	view →
BRCA	All	III,IV	+0.413	.013	4	view →
CHOL	All	All	+0.906	<.001	3	view →
ESCA	All	All	+0.970	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HEXB–HNSC

Open the HNSC breakdown →