HERPUD2

Across TCGA cell cohorts, HERPUD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,301 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HERPUD2-associated GO terms across cancer lineages are ER-nucleus signaling pathway, Positive regulation of exosomal secretion, and Endoplasmic reticulum unfolded protein response. Each is linked with HERPUD2 in more than 13 cancer types. Because this analysis shows association rather than direction, both HERPUD2-to-partner and partner-to-HERPUD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-nucleus signaling pathway grouped by HERPUD2-low versus HERPUD2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HERPUD2→partner) and Y-score (partner→HERPUD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ER-nucleus signaling pathway →	+0.124	+0.855	<.001	<.001	3	14
OVARY	Positive regulation of exosomal secretion →	+0.111	+0.584	<.001	.002	3	14
PANCREAS	Endoplasmic reticulum unfolded protein response →	+0.084	+0.418	.002	.007	3	13
SOFT_TISSUE	Cellular response to unfolded protein →	+0.087	+0.789	<.001	<.001	3	13
PANCREAS	Response to endoplasmic reticulum stress →	+0.052	+0.393	.001	.002	3	13
SOFT_TISSUE	Cellular response to topologically incorrect protein →	+0.078	+0.656	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,301 associations by consensus.

ER-nucleus signaling pathway by HERPUD2 expression — STOMACH

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