HERPUD2

Across TCGA pan-cancer cohorts, HERPUD2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HERPUD2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HERPUD2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HERPUD2 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where HERPUD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HERPUD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.735	<.001	12	view →
KIRC	Male	IV	+0.752	<.001	11	view →
LIHC	All	III,IV	+0.676	<.001	9	view →
KIRP	All	All	+0.388	.001	9	view →
THCA	Male	All	−0.337	<.001	8	view →
UCEC	All	All	−0.752	<.001	6	view →
CHOL	All	All	+1.048	<.001	5	view →
KICH	Female	All	−0.648	.001	3	view →
BRCA	Female	All	−0.141	.010	3	view →
ESCA	Female	All	+0.913	.036	1	view →
STAD	All	II,III,IV	+0.315	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HERPUD2–HNSC

Open the HNSC breakdown →