HERPUD2

Across TCGA pan-cancer cohorts, HERPUD2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HERPUD2 data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher HERPUD2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HERPUD2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

CESC, KIRC, and BLCA are the cancer types where HERPUD2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Quartile	III,IV	0.241	0.741	.005	92	view →
KIRC	OS	Tertile	All	0.725	0.540	<.001	89	view →
BLCA	DFS	Quartile	All	0.236	0.706	<.001	57	view →
ACC	DFS	Tertile	II,III,IV	0.249	0.734	<.001	44	view →
HNSC	OS	Median	III,IV	0.579	0.732	.003	38	view →
KIRP	DFS	Tertile	II,III,IV	0.406	1.000	.013	33	view →
SKCM	OS	Tertile	II,III,IV	0.371	0.167	.001	30	view →
UCS	DFS	Median	IV	0.909	0.416	.008	30	view →
LGG	OS	Tertile	All	0.744	0.847	.009	14	view →
LIHC	DFS	Quartile	All	0.278	0.613	.002	12	view →
UVM	DFS	Quartile	II,III,IV	0.304	0.737	.015	10	view →
STAD	DFS	Median	All	0.342	0.631	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

HERPUD2–CESC (DFS)

Open the CESC breakdown →