HERC2P4

Across TCGA patient cohorts, HERC2P4 mutation is significantly associated with the RNA expression of many other genes, with 264 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HERC2P4-associated genes across cancer lineages are LINC01580, MIR4804, and MIR6803. Each is linked with HERC2P4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HERC2P4-to-partner and partner-to-HERC2P4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01580 grouped by HERC2P4-low versus HERC2P4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC2P4→partner) and Y-score (partner→HERC2P4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC01580 →	+0.816	+3.669	.002	.007	3	2
SKCM	MIR4804 →	+0.405	+3.923	<.001	.003	3	2
UCEC	MIR6803 →	+0.212	+5.019	<.001	.001	3	2
SKCM	SNORD82 →	+0.562	+4.043	<.001	.001	3	2
BRCA	MIR6082 →	+0.186	+7.471	<.001	.008	3	1
UCEC	TANGO2 →	+0.518	+3.595	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 264 associations by consensus.

LINC01580 by HERC2P4 expression — SKCM

Explore this box plot interactively →