HERC2P3

Across TCGA patient cohorts, HERC2P3 mutation is significantly associated with the RNA expression of many other genes, with 2,836 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HERC2P3-associated genes across cancer lineages are ALDOAP1, POLR3K, and TEDC2. Each is linked with HERC2P3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HERC2P3-to-partner and partner-to-HERC2P3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALDOAP1 grouped by HERC2P3-low versus HERC2P3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC2P3→partner) and Y-score (partner→HERC2P3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ALDOAP1 →	+0.157	+1.516	<.001	.007	3	3
UCEC	POLR3K →	+0.481	+4.269	<.001	<.001	3	3
UCEC	TEDC2 →	+0.608	+2.454	<.001	<.001	3	3
UCEC	CDT1 →	+0.894	+2.465	<.001	<.001	3	3
UCEC	CHAF1A →	+0.718	+1.857	<.001	<.001	3	3
UCEC	FEN1 →	+0.699	+2.147	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,836 associations by consensus.

ALDOAP1 by HERC2P3 expression — SKCM

Explore this box plot interactively →