HERC2P3

Across TCGA pan-cancer cohorts, HERC2P3 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated HERC2P3 data layer compared with 8 for mutation status.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher HERC2P3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HERC2P3 expression acts as an unfavorable survival marker, although some lineages such as ESCA and SKCM show a favorable association.

ESCA, LUSC, and THCA are the cancer types where HERC2P3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	III,IV	0.685	0.422	.001	65	view →
LUSC	DFS	Quartile	II,III,IV	0.219	0.520	.001	43	view →
THCA	DFS	Quartile	All	0.688	0.956	<.001	42	view →
STAD	DFS	Tertile	All	0.464	0.641	.011	34	view →
CESC	DFS	Tertile	All	0.430	0.649	.010	28	view →
SKCM	OS	Quartile	All	0.469	0.274	<.001	24	view →
COAD	OS	Tertile	III,IV	0.434	0.778	.009	20	view →
UVM	DFS	Median	III,IV	0.472	0.832	.005	13	view →
BLCA	OS	Quartile	All	0.801	0.659	.010	13	view →
LGG	OS	Median	All	0.630	0.438	.004	11	view →
UCEC	OS	Median	III,IV	0.669	0.485	.027	10	view →
DLBC	DFS	Tertile	III,IV	0.122	0.984	.004	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

HERC2P3–ESCA (OS)

Open the ESCA breakdown →