Across TCGA patient cohorts, HEPN1 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HEPN1-associated genes across cancer lineages are URGCP-MRPS24, RNU6-363P, and RNU6-992P. Each is linked with HEPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEPN1-to-partner and partner-to-HEPN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEPN1→partner) and Y-score (partner→HEPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	URGCP-MRPS24 →	+0.338	+3.643	<.001	.003	3	1
COAD	RNU6-363P →	+1.355	+7.741	<.001	.009	3	1
COAD	RNU6-992P →	+0.618	+7.741	<.001	.009	3	1
COAD	RNU6-1210P →	+1.487	+7.741	<.001	.009	3	1
COAD	RNU6-967P →	+0.942	+7.741	<.001	.009	3	1
COAD	RNU6-741P →	+0.622	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Exploration

HEPN1 survival (RNA) · tumor vs normal (RNA) · all HEPN1 data types