HENMT1

Across TCGA patient cohorts, HENMT1 mutation is significantly associated with the RNA expression of many other genes, with 627 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HENMT1-associated genes across cancer lineages are RPL22P14, RNU6-502P, and PEX5L-AS2. Each is linked with HENMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HENMT1-to-partner and partner-to-HENMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL22P14 grouped by HENMT1-low versus HENMT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HENMT1→partner) and Y-score (partner→HENMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL22P14 →	+0.117	+2.618	<.001	<.001	3	2
BLCA	RNU6-502P →	+0.272	+4.588	<.001	.008	3	2
LUAD	PEX5L-AS2 →	+0.543	+5.099	<.001	.008	3	2
LUAD	LINC02103 →	+0.167	+5.798	<.001	.003	3	2
COAD	MIR548J →	+0.458	+4.418	<.001	.008	3	2
COAD	LINC00498 →	+0.192	+4.308	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 627 associations by consensus.

RPL22P14 by HENMT1 expression — UCEC

Explore this box plot interactively →