HENMT1

Across TCGA pan-cancer cohorts, HENMT1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HENMT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HENMT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HENMT1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, BLCA, and KICH are the cancer types where HENMT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HENMT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.418	<.001	12	view →
BLCA	All	III,IV	+1.647	<.001	10	view →
KICH	All	II,III,IV	−1.599	<.001	9	view →
STAD	Female	All	+1.898	<.001	8	view →
THCA	All	II,III,IV	−0.599	<.001	8	view →
COAD	Male	All	+0.931	<.001	7	view →
KIRP	All	All	−0.688	<.001	7	view →
BRCA	All	II,III,IV	+0.359	.006	6	view →
CHOL	Male	All	+2.706	<.001	5	view →
READ	All	All	+1.310	<.001	5	view →
LUAD	Male	All	+0.832	<.001	3	view →
LUSC	All	All	+0.582	.005	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HENMT1–HNSC

Open the HNSC breakdown →