HELLS

Across TCGA patient cohorts, HELLS RNA expression is significantly associated with the protein abundance of many other proteins, with 24,688 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HELLS-associated proteins across cancer lineages are UNG_T60, POLD1, and RPL12_S38. Each is linked with HELLS in more than 9 cancer types. Because this analysis shows association rather than direction, both HELLS-to-partner and partner-to-HELLS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HELLS versus UNG_T60 in LUAD, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HELLS→partner) and Y-score (partner→HELLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UNG_T60 →	+1.170	+1.146	<.001	<.001	3	10
BRCA	POLD1 →	+0.377	+0.763	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.197	+0.984	<.001	<.001	3	10
UCEC	RRM1 →	+0.715	+0.827	<.001	<.001	3	10
GBM	SMC2 →	+0.696	+0.962	<.001	<.001	3	10
LUAD	SMC4 →	+0.658	+0.973	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 24,688 associations by consensus.

HELLS vs UNG_T60 — LUAD

Explore this scatter interactively →