HELLS

Across TCGA pan-cancer cohorts, HELLS RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HELLS data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HELLS RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HELLS expression acts as an unfavorable survival marker, although some lineages such as LUSC and CESC show a favorable association.

ACC, MESO, and KIRP are the cancer types where HELLS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.330	0.876	<.001	145	view →
MESO	OS	Median	All	0.241	0.540	<.001	120	view →
KIRP	OS	Median	All	0.512	0.823	<.001	99	view →
LIHC	DFS	Median	All	0.443	0.632	<.001	96	view →
KICH	DFS	Quartile	III,IV	0.085	1.000	.001	62	view →
LUSC	OS	Median	All	0.735	0.609	.001	61	view →
LUAD	OS	Median	All	0.617	0.745	<.001	52	view →
LGG	OS	Median	All	0.736	0.882	<.001	47	view →
SARC	DFS	Median	All	0.535	0.687	<.001	38	view →
KIRC	DFS	Median	II,III,IV	0.397	0.662	<.001	32	view →
CESC	OS	Tertile	All	0.872	0.740	.017	24	view →
GBM	DFS	Tertile	All	0.513	0.184	<.001	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HELLS–ACC (OS)

Open the ACC breakdown →