HELLS

Across TCGA patient cohorts, HELLS protein abundance is significantly associated with the RNA expression of many other genes, with 14,185 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HELLS-associated genes across cancer lineages are CENPM, MCM4, and PIMREG. Each is linked with HELLS in more than 6 cancer types. Because this analysis shows association rather than direction, both HELLS-to-partner and partner-to-HELLS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HELLS versus CENPM in GBM, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELLS→partner) and Y-score (partner→HELLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CENPM →	+1.683	+0.820	<.001	<.001	3	7
GBM	MCM4 →	+1.039	+0.812	<.001	<.001	3	7
GBM	PIMREG →	+1.675	+0.947	<.001	<.001	3	7
GBM	GINS2 →	+1.321	+0.889	<.001	<.001	3	7
LUAD	CEP55 →	+1.196	+0.501	<.001	<.001	3	7
LUAD	KIF20B →	+0.723	+0.448	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,185 associations by consensus.

HELLS vs CENPM — GBM

Explore this scatter interactively →