HECW1

Across TCGA cell cohorts, HECW1 mutation is significantly associated with the RNA expression of many other genes, with 790 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HECW1-associated genes across cancer lineages are ACBD5, LRTM1, and IQCF5. Each is linked with HECW1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HECW1-to-partner and partner-to-HECW1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACBD5 grouped by HECW1-low versus HECW1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECW1→partner) and Y-score (partner→HECW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACBD5 →	+0.666	+1.483	.001	.002	3	3
BONE	LRTM1 →	+0.040	+4.000	<.001	.008	3	2
BLOOD_Leukemia	IQCF5 →	+0.042	+2.979	<.001	.007	3	2
LARGE_INTESTINE	CCDC28A-AS1 →	+0.313	+1.299	.004	.006	2	3
LARGE_INTESTINE	TNFRSF10A →	+0.714	+1.569	.001	.001	3	2
LARGE_INTESTINE	ABHD17B →	+0.449	+3.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 790 associations by consensus.

ACBD5 by HECW1 expression — LARGE_INTESTINE

Explore this box plot interactively →