HECW1

Across TCGA pan-cancer cohorts, HECW1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HECW1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HECW1 RNA is repressed in tumor relative to normal tissue. In most cancer types HECW1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where HECW1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HECW1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−1.360	<.001	12	view →
HNSC	All	III,IV	+0.570	<.001	12	view →
THCA	Male	II,III,IV	−0.602	<.001	11	view →
COAD	Male	All	+0.305	<.001	10	view →
LUAD	Male	All	+0.601	<.001	9	view →
LUSC	Male	All	+0.566	<.001	8	view →
KICH	Female	All	−1.475	<.001	7	view →
KIRP	Male	All	−1.444	<.001	6	view →
BLCA	All	III,IV	+0.519	.004	6	view →
STAD	All	II,III,IV	+0.169	<.001	6	view →
LIHC	All	All	+0.130	.010	4	view →
PRAD	All	All	−0.490	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HECW1–KIRC

Open the KIRC breakdown →