HECW1-IT1

Across TCGA patient cohorts, HECW1-IT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,635 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HECW1-IT1-associated GO terms across cancer lineages are Cellular senescence, Negative regulation of Wnt signaling pathway, and Protein-containing complex disassembly. Each is linked with HECW1-IT1 in more than 15 cancer types. Because this analysis shows association rather than direction, both HECW1-IT1-to-partner and partner-to-HECW1-IT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular senescence grouped by HECW1-IT1-low versus HECW1-IT1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HECW1-IT1→partner) and Y-score (partner→HECW1-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Cellular senescence →	+0.073	+0.097	<.001	.003	3	15
ESCA	Negative regulation of Wnt signaling pathway →	+0.066	+0.125	<.001	.002	3	15
STAD	Protein-containing complex disassembly →	+0.063	+0.090	<.001	<.001	3	14
ESCA	Regulation of cell cycle G1/S phase transition →	+0.076	+0.142	<.001	.001	3	14
ESCA	Response to amino acid starvation →	+0.075	+0.115	<.001	.003	3	14
STAD	Regulation of cellular senescence →	+0.060	+0.092	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,635 associations by consensus.

Cellular senescence by HECW1-IT1 expression — ESCA

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