HECW1-IT1

Across TCGA pan-cancer cohorts, HECW1-IT1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of HECW1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HECW1-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HECW1-IT1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, THCA, and LUSC are the cancer types where HECW1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HECW1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+0.025	.011	8	view →
THCA	All	All	−0.013	.006	4	view →
LUSC	Female	All	+0.012	.032	1	view →
STAD	Male	All	+0.011	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

HECW1-IT1–HNSC

Open the HNSC breakdown →