HEBP2

Across TCGA patient cohorts, HEBP2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEBP2-associated genes across cancer lineages are JNK_pT183_Y185, Myosin-IIa, and Rab25. Each is linked with HEBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEBP2-to-partner and partner-to-HEBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by HEBP2-low versus HEBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEBP2→partner) and Y-score (partner→HEBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.242	-3.156	.008	.020	3	1
UCEC	Myosin-IIa →	+0.412	+3.007	<.001	.019	3	1
UCEC	Rab25 →	-0.531	-3.169	.003	.020	2	1
UCEC	Tuberin_pT1462 →	+0.454	+3.179	<.001	.010	2	1
UCEC	EGFR_pY1068 →	-0.334	-3.169	.015	.020	1	1
UCEC	eIF4E →	+0.258	+3.169	.025	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

JNK_pT183_Y185 by HEBP2 expression — UCEC

Explore this box plot interactively →