HEBP2

Across TCGA pan-cancer cohorts, HEBP2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HEBP2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where HEBP2 RNA is repressed in tumor relative to normal tissue. In most cancer types HEBP2 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, LUAD, and BRCA are the cancer types where HEBP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HEBP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−1.194	<.001	11	view →
LUAD	Male	II,III,IV	+0.733	<.001	8	view →
BRCA	All	III,IV	−0.697	<.001	8	view →
LUSC	Female	All	+1.042	<.001	7	view →
HNSC	Female	All	−0.559	.001	6	view →
COAD	All	II,III,IV	+0.354	.001	6	view →
KIRC	All	All	+0.208	.002	5	view →
CHOL	All	II,III,IV	+1.395	.003	4	view →
BLCA	Male	All	+0.535	.033	4	view →
PRAD	All	All	+0.542	<.001	2	view →
UCEC	All	All	+0.486	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HEBP2–KICH

Open the KICH breakdown →