HEBP2

Across TCGA pan-cancer cohorts, HEBP2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated HEBP2 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher HEBP2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HEBP2 expression acts as an unfavorable survival marker, although some lineages such as BLCA and THYM show a favorable association.

ESCA, LUAD, and OV are the cancer types where HEBP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.578	0.829	<.001	78	view →
LUAD	OS	Median	All	0.254	0.461	<.001	59	view →
OV	DFS	Median	II,III,IV	0.331	0.429	.003	54	view →
LGG	OS	Median	All	0.717	0.904	<.001	53	view →
UCEC	DFS	Quartile	IV	0.479	0.977	.006	38	view →
BLCA	DFS	Tertile	II,III,IV	0.498	0.327	.010	34	view →
LAML	DFS	Tertile	All	0.354	0.698	.006	30	view →
DLBC	DFS	Median	III,IV	0.423	1.000	.005	29	view →
THYM	OS	Median	All	1.000	0.919	.010	25	view →
KIRP	DFS	Tertile	All	0.791	0.922	.020	25	view →
ACC	OS	Median	IV	0.777	0.309	.019	24	view →
THCA	OS	Quartile	II,III,IV	1.000	0.956	.010	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

HEBP2–ESCA (OS)

Open the ESCA breakdown →