HDX

Across TCGA patient cohorts, HDX protein abundance is significantly associated with the RNA expression of many other genes, with 591 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HDX-associated genes across cancer lineages are TRBV9, CELF4, and ZC3H12B. Each is linked with HDX in more than 1 cancer types. Because this analysis shows association rather than direction, both HDX-to-partner and partner-to-HDX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDX versus TRBV9 in BRCA, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDX→partner) and Y-score (partner→HDX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRBV9 →	+1.484	+0.980	.001	.002	3	2
LSCC	CELF4 →	+0.397	+2.173	.001	.005	3	1
LSCC	ZC3H12B →	+0.623	+2.486	.007	.009	3	1
LSCC	CLN5 →	+0.689	+2.273	<.001	.009	3	1
LSCC	GNRHR →	+1.023	+2.173	.002	.005	3	1
LSCC	GLRB →	+1.218	+2.173	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 591 associations by consensus.

HDX vs TRBV9 — BRCA

Explore this scatter interactively →