HDX

Across TCGA pan-cancer cohorts, HDX RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HDX data layer compared with 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HDX RNA is associated with better overall survival. In most high-consensus cancer types, elevated HDX expression acts as an unfavorable survival marker, although some lineages such as COAD and PAAD show a favorable association.

COAD, PAAD, and UCEC are the cancer types where HDX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.809	0.523	<.001	71	view →
PAAD	OS	Median	All	0.707	0.521	<.001	64	view →
UCEC	DFS	Median	All	0.552	0.738	<.001	60	view →
SCLC	DFS	Tertile	II,III,IV	0.809	0.414	.002	57	view →
KIRC	DFS	Median	All	0.854	0.733	.006	51	view →
ESCA	OS	Quartile	II,III,IV	0.727	0.318	.001	37	view →
STAD	OS	Quartile	All	0.361	0.736	.009	21	view →
LIHC	OS	Median	III,IV	0.575	0.216	.010	20	view →
KIRP	DFS	Quartile	All	0.840	0.979	.002	18	view →
CHOL	DFS	Tertile	All	1.000	0.123	.011	15	view →
UCS	DFS	Tertile	II,III,IV	0.529	0.119	.028	14	view →
SKCM	DFS	Median	All	0.665	0.550	.005	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HDX–COAD (OS)

Open the COAD breakdown →