HDHD5

Across TCGA patient cohorts, HDHD5 mutation is significantly associated with the RNA expression of many other genes, with 1,812 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDHD5-associated genes across cancer lineages are SPCS2P2, RNA5SP516, and TOMM22P5. Each is linked with HDHD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDHD5-to-partner and partner-to-HDHD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPCS2P2 grouped by HDHD5-low versus HDHD5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDHD5→partner) and Y-score (partner→HDHD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SPCS2P2 →	+0.096	+5.343	<.001	.006	3	2
UCEC	RNA5SP516 →	+0.315	+3.063	<.001	.007	3	2
UCEC	TOMM22P5 →	+0.266	+2.424	<.001	.003	3	2
UCEC	EIF3JP1 →	+0.349	+3.105	<.001	<.001	3	2
LUSC	RNU6-158P →	+0.479	+3.956	<.001	.005	3	2
SKCM	MIR1261 →	+0.632	+3.393	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,812 associations by consensus.

SPCS2P2 by HDHD5 expression — LUAD

Explore this box plot interactively →