Across TCGA patient cohorts, HDDC3 mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDDC3-associated genes across cancer lineages are PROP1, SNRPGP17, and HMGB1P50. Each is linked with HDDC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDDC3-to-partner and partner-to-HDDC3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDDC3→partner) and Y-score (partner→HDDC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PROP1 →	+0.362	+3.585	<.001	.009	3	1
UCEC	SNRPGP17 →	+0.550	+4.463	<.001	<.001	3	1
UCEC	HMGB1P50 →	+0.343	+3.735	<.001	.001	3	1
UCEC	OR6R2P →	+0.576	+3.383	<.001	.003	3	1
UCEC	RN7SL248P →	+0.118	+4.400	<.001	.006	3	1
UCEC	RN7SL478P →	+0.486	+3.676	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Exploration

HDDC3 survival (RNA) · tumor vs normal (RNA) · all HDDC3 data types