HDAC9

Across TCGA patient cohorts, HDAC9 mutation is significantly associated with the RNA expression of many other genes, with 6,970 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC9-associated genes across cancer lineages are CDKN3, TIPIN, and ORC1. Each is linked with HDAC9 in more than 5 cancer types. Because this analysis shows association rather than direction, both HDAC9-to-partner and partner-to-HDAC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN3 grouped by HDAC9-low versus HDAC9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC9→partner) and Y-score (partner→HDAC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDKN3 →	+0.800	+1.818	<.001	<.001	3	6
UCEC	TIPIN →	+0.529	+2.230	<.001	<.001	3	5
UCEC	ORC1 →	+0.796	+1.628	<.001	<.001	3	5
UCEC	CLSPN →	+0.736	+1.628	<.001	<.001	3	5
UCEC	CDCA2 →	+0.952	+2.209	<.001	<.001	3	5
UCEC	ARHGAP11A →	+0.682	+1.470	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,970 associations by consensus.

CDKN3 by HDAC9 expression — UCEC

Explore this box plot interactively →