HDAC9

Across TCGA cell cohorts, HDAC9 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,992 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible HDAC9-associated GO terms across cancer lineages are Cytoplasmic pattern recognition receptor signaling pathway, Caveola assembly, and Cellular response to environmental stimulus. Each is linked with HDAC9 in more than 10 cancer types. Because this analysis shows association rather than direction, both HDAC9-to-partner and partner-to-HDAC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic pattern recognition receptor signaling pathway grouped by HDAC9-low versus HDAC9-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC9→partner) and Y-score (partner→HDAC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Cytoplasmic pattern recognition receptor signaling pathway →	+0.067	+1.545	<.001	.002	3	11
BREAST	Caveola assembly →	+0.182	+1.255	<.001	.003	3	11
CNS	Cellular response to environmental stimulus →	+0.043	+1.696	<.001	<.001	3	10
CNS	Cellular response to abiotic stimulus →	+0.043	+1.696	<.001	<.001	3	10
BREAST	Xenobiotic export from cell →	-0.157	-1.717	.001	<.001	3	10
LARGE_INTESTINE	Oncogene-induced cell senescence →	+0.142	+1.273	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,992 associations by consensus.

Cytoplasmic pattern recognition receptor signaling pathway by HDAC9 expression — LUNG_NSCLC_LUAD

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