HDAC1

Across TCGA patient cohorts, HDAC1 mutation is significantly associated with the RNA expression of many other genes, with 2,809 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC1-associated genes across cancer lineages are MIR548AY, RNA5-8SN1, and RNA5-8SN2. Each is linked with HDAC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC1-to-partner and partner-to-HDAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548AY grouped by HDAC1-low versus HDAC1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC1→partner) and Y-score (partner→HDAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR548AY →	+0.486	+3.980	<.001	<.001	3	1
BRCA	RNA5-8SN1 →	+0.556	+4.716	<.001	.004	3	1
BRCA	RNA5-8SN2 →	+0.419	+4.628	<.001	.004	3	1
BRCA	CTBP2P9 →	+0.035	+4.317	<.001	.007	3	1
UCEC	LIN7C →	+0.769	+2.928	<.001	.001	3	1
UCEC	IMMP1L →	+0.450	+2.917	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,809 associations by consensus.

MIR548AY by HDAC1 expression — BRCA

Explore this box plot interactively →