HDAC1

Across TCGA pan-cancer cohorts, HDAC1 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of HDAC1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HDAC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HDAC1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, LUSC, and LUAD are the cancer types where HDAC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HDAC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.868	<.001	12	view →
LUSC	Female	All	+1.338	<.001	9	view →
LUAD	Male	II,III,IV	+0.853	<.001	9	view →
LIHC	Female	II,III,IV	+1.272	<.001	8	view →
STAD	Male	II,III,IV	+1.272	<.001	8	view →
KICH	Female	II,III,IV	−1.932	<.001	7	view →
BRCA	All	III,IV	+0.762	<.001	6	view →
BLCA	All	All	+0.595	.006	6	view →
CHOL	Male	All	+2.256	<.001	5	view →
PAAD	All	All	+0.837	.022	4	view →
UCEC	All	III,IV	+0.578	.022	4	view →
ESCA	All	All	+1.139	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

HDAC1–HNSC

Open the HNSC breakdown →