HCRT

Across TCGA patient cohorts, HCRT mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCRT-associated genes across cancer lineages are CD8+ T-cells and CD8+ Tcm. Each is linked with HCRT in more than 1 cancer types. Because this analysis shows association rather than direction, both HCRT-to-partner and partner-to-HCRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by HCRT-low versus HCRT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCRT→partner) and Y-score (partner→HCRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ T-cells →	+0.050	+4.845	<.001	.011	3	1
UCEC	CD8+ Tcm →	+0.104	+4.935	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD8+ T-cells by HCRT expression — UCEC

Explore this box plot interactively →