HCRT

Across TCGA pan-cancer cohorts, HCRT RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of HCRT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HCRT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HCRT is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where HCRT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HCRT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.561	<.001	10	view →
HNSC	Male	III,IV	+0.126	.012	5	view →
LIHC	All	All	+0.076	<.001	4	view →
ESCA	Female	All	+0.156	.012	3	view →
KICH	All	All	−0.135	.003	3	view →
CHOL	Female	All	+0.156	<.001	2	view →
LUSC	All	II,III,IV	−0.076	.002	2	view →
STAD	Male	II,III,IV	+0.190	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

HCRT–COAD

Open the COAD breakdown →