HCRT

Across TCGA pan-cancer cohorts, HCRT RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HCRT data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher HCRT RNA is associated with better overall survival. In most high-consensus cancer types, elevated HCRT expression acts as an unfavorable survival marker, although some lineages such as READ and COAD show a favorable association.

READ, COAD, and LGG are the cancer types where HCRT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.976	0.853	.001	50	view →
COAD	DFS	Quartile	IV	0.771	0.314	.001	50	view →
LGG	DFS	Median	All	0.648	0.814	<.001	44	view →
BLCA	OS	Tertile	II,III,IV	0.538	0.357	.002	44	view →
KICH	DFS	Quartile	III,IV	0.032	0.865	.001	28	view →
GBM	OS	Quartile	All	0.291	0.509	<.001	27	view →
ACC	OS	Quartile	III,IV	0.299	0.651	.002	17	view →
HNSC	OS	Tertile	All	0.757	0.659	.040	15	view →
PAAD	OS	Quartile	All	0.662	0.268	.004	15	view →
MESO	OS	Quartile	III,IV	0.204	0.620	.010	14	view →
SKCM	OS	Tertile	II,III,IV	0.897	0.812	.014	12	view →
UCS	DFS	Quartile	II,III,IV	0.674	0.308	.027	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

HCRT–READ (OS)

Open the READ breakdown →