HCN2

Across TCGA cell cohorts, HCN2 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HCN2-associated genes across cancer lineages are KHDC3L, PRAMEF10, and PRAMEF17. Each is linked with HCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCN2-to-partner and partner-to-HCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KHDC3L grouped by HCN2-low versus HCN2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN2→partner) and Y-score (partner→HCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KHDC3L →	+0.015	+3.632	.001	.003	3	2
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF14 →	+0.275	+4.523	<.001	.003	3	1
LUNG_SCLC	OR13C5 →	+0.037	+4.817	<.001	.001	3	1
BLOOD_Lymphoma	TECTB →	+0.028	+3.794	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

KHDC3L by HCN2 expression — SKIN

Explore this box plot interactively →