HCN2

Across TCGA pan-cancer cohorts, HCN2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HCN2 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HCN2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HCN2 expression acts as an unfavorable survival marker, although some lineages such as THYM and PAAD show a favorable association.

KIRC, UVM, and BLCA are the cancer types where HCN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.544	0.707	<.001	120	view →
UVM	DFS	Median	All	0.422	0.770	<.001	85	view →
BLCA	DFS	Quartile	All	0.222	0.538	.001	60	view →
ACC	DFS	Median	All	0.176	0.674	.002	52	view →
KIRP	DFS	Median	IV	0.038	0.527	.010	49	view →
COAD	OS	Median	All	0.469	0.700	.003	46	view →
LUAD	OS	Median	All	0.317	0.411	.002	37	view →
THYM	OS	Median	II,III,IV	0.954	0.703	.009	19	view →
PAAD	OS	Quartile	All	0.640	0.265	.002	18	view →
CHOL	OS	Median	III,IV	1.000	0.286	.008	15	view →
MESO	OS	Quartile	III,IV	0.396	0.752	.006	12	view →
UCS	OS	Quartile	All	0.292	0.652	.039	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HCN2–KIRC (OS)

Open the KIRC breakdown →